Be wary, manage side effects of TB drug linezolid: Mayo study – ET HealthWorld


Nagpur: A new international study conducted by the respiratory medicine department of the Indira Gandhi Government Medical College (IGGMC) and Mayo Hospital has shed light on the management of drug-resistant tuberculosis, providing insights into potential side effects of the commonly used drug linezolid.

The study, titled ‘Adverse Drug Reactions Due to linezolid in the Programmatic Management of Drug-Resistant Tuberculosis in India: A Retrospective Multicenter Study’, was conducted on 106 patients with multidrug-resistant and rifampicin-resistant tuberculosis from March 2020 to April 2022. It was published in the April 2023 edition of the Indian Journal of Tuberculosis.

The study found that 42.45 per cent of patients experienced linezolid-attributable side effects, with peripheral neuropathy being the most common side effect, observed in 93.33 per cent of these patients. Other infrequent linezolid-associated side effects were difficulty in vision (optic neuritis), fatigue, weakness, and pallor (anaemia), and pain in the abdomen, vomiting (lactic acidosis).

The lead author of the study was Dr Gyanshankar Mishra, associate professor of respiratory medicine at Indira Gandhi Government Medical College in Nagpur, who was joined by co-authors including Jan-Willem Alffennar from the Sydney Institute of Infectious Diseases at the University of Sydney, Australia; Dr Radha Munje, professor and head of respiratory medicine at IGGMC Nagpur; and Dr Sadaf Khateeb, medical officer, NTEP, IGGMC-TB unit.

“Women and young TB patients are at higher risk of linezolid-attributable adverse drug reactions (ADRs). Therefore, it is important for people with drug-resistant TB to be aware of these side effects,” said Dr Mishra. He appealed patients to report symptoms, especially tingling or burning sensations in the hands or feet, to their doctor immediately.

Despite potential adverse reactions, the new treatment regime for MDR-TB is a significant step forward in treating this TB, said doctors. This is the reason they have suggested symptom management.

  • Published On May 8, 2023 at 01:45 PM IST

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